If the goal is to measure large scale structures, such as genomic compartments, then a lower resolution will often suffice (1MB-10MB), then we'll choose a proper bin size. However if the goal is to measure specific interactions of a small region, e.g. promoter-enhancer looping, then one should choose to use a restriction enzyme that cuts more frequently (e.g. 4bp) and a method that does not measure the entire genome, but instead focuses on exploring only a subset of the genome (i.e. 3C/4C/5C).