# Chap1 Why we care about 3D genome

## Better understanding of life from a higher dimension view

Around 15 years ago, one of the greatest feats of exploration in history - The Human Genome Project (HGP) was completed. This inward voyage to explore the sequence and map all of the genes - together known as the genome - of Homo sapiens. It gave us the ability to read nature's complete genetic blueprint for building a human being. By leveraging the comprehensive sequence map, we gained insight of how these simple life codes are associated with life development, disease, evolution so on and so forth.

*"two sequence whisper, multiple sequences shout" —— Arthur M. Lesk*

However, the mystery of life can never be simply understood in the view of a linear structure. Instead, just as we understand the complexity of a jungle by walking through it, obersving the hierachical niches and biological diversity rather than a birdview with green patches companied with blue lines from the google map, a 3D genome architecture further integrate a time dimension can provide a much more comprehensive knowledge for understanding the life.

*“Genes and regulatory elements are like people, They care about and communicate with those in their own domain, and they ignore everything else.” —— Job Dekker*