# Chap1 Why we care about 3D genome ## Better understanding of life from a higher dimension view Around 15 years ago, one of the greatest feats of exploration in history - The Human Genome Project (HGP) was completed. This inward voyage to explore the sequence and map all of the genes - together known as the genome - of Homo sapiens. It gave us the ability to read nature's complete genetic blueprint for building a human being. By leveraging the comprehensive sequence map, we gained insight of how these simple life codes are associated with life development, disease, evolution so on and so forth. *"two sequence whisper, multiple sequences shout" —— Arthur M. Lesk* However, the mystery of life can never be simply understood in the view of a linear structure. Instead, just as we understand the complexity of a jungle by walking through it, obersving the hierachical niches and biological diversity rather than a birdview with green patches companied with blue lines from the google map, a 3D genome architecture further integrate a time dimension can provide a much more comprehensive knowledge for understanding the life. *“Genes and regulatory elements are like people, They care about and communicate with those in their own domain, and they ignore everything else.” —— Job Dekker* --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://zhonglab.gitbook.io/3dgenome/chapter1-why-we-care-about-3d-genome.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.